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Action and forms of Klonopin

Clonazepam is an active substance of Klonopin. It has an anticonvulsant, anxiolytic, sedative, hypnotic, and myorelaxing action. The drug Klonopin is available in the form of tablets containing 0.5, 1.0 and 2.0 mg of original or generic clonazepam. Clonazepam is also available in the form of soluble tablets of 0.125, 0.25 and 0.50 mg.

Uses of Klonopin

Clonazepam inhibits epileptiform activity; therefore, it is used in the treatment of epilepsy and epileptic syndromes. It is used as an independent or as an adjuvant drug for the treatment of the Lennox-Gastaut syndrome (petit mal), akinetic and myoclonic seizures. Klonopin is used for the treatment of absences (petit mal) in case of the ineffectiveness of anticonvulsants of succinimides or valproic acid, for the treatment of focal epileptic seizures, including refractory (complex focal – psychomotor, temporal lobe, and elementary) and tonic-clonic (grand mal) seizures. However, when prescribing clonazepam to patients who have seizures of various types, it should be borne in mind that it is the increase of the frequency or acceleration of the development of generalized tonic-clonic epileptic seizures is possible, which may require an additional administration of another anticonvulsant and/or an increased dose of clonazepam. Clonazepam is used (alone or as an adjuvant) to treat neuroleptic-induced akathisia, alleviate the symptoms of catalepsy and dyskinesia caused by medication. It is effective in treating migraine headaches, organic brain syndrome, acute mania, restless legs syndrome, trigeminal neuralgia, spasms in infants, convulsions with eclampsia, epileptic seizures caused by fright, and a number of resistant convulsive conditions. It helps to cope with an increased muscle tone, sleep disorders, and panic disorders.

Adverse effects

Dose-dependent side effects include drowsiness, ataxia, behavioral disorders (irritability, depression, psychosis), dysarthria, and diplopia. Idiosyncrasy reactions are usually represented by a skin rash and rarely include hair loss, anemia, leukopenia, and thrombocytopenia.

Special instructions

A reduction in the dose of the drug may be required for patients with liver disease. Based on the experience of using other benzodiazepine drugs during pregnancy, it is believed that taking Clonazepam in the first trimester of pregnancy is associated with an increased risk of developing congenital anomalies. Clonazepam enters the breast milk and can cause sedation in newborns. Simultaneous intake of amphetamines or methylphenidate with clonazepam may cause the CNS depression and respiratory disturbances. The oppressive effect of clonazepam on the central nervous system can be increased by alcohol, anxiolytics, antipsychotics, antidepressants, and other antiepileptic drugs.